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Summary of Discovery Projects Applications for Funding to Commence in 2006

Queensland

The University of Queensland

DP0667070 Dr MA Adamska

Approved Origin of multicellularity in animals: identification and analysis of intercellular signalling pathways

Project Title in a basal metazoan, the demosponge Reniera

2006 : $75,000

2007 : $65,000

2008 : $65,000

Primary RFCD 2702 GENETICS

Administering Institution The University of Queensland

Project Summary

The Reniera genome project is a multi‑million dollar collaboration between JGI (US‑DOE) and Australian scientists that will

see the sequencing of the first Australian marine animal by 2006. This project will significantly advance our understanding of

the origins of animals and contribute to the reconstruction of creatures that lived over 600 million years ago. A major

outcome of this reconstruction will be a fundamental understanding of how cells communicate with each other during the

process of development to give rise to the diversity of cell types within multicellular animals. This study will also shed light on

what happens when cell communication goes astray, as observed in a range of human malignancies, including cancer.

DP0663809 Dr M Alauddin; Prof DP Rao; Prof TJ Coelli

Approved The Sustainability of Agricultural Productivity Growth in a Changing Environment: An International

Project Title Perspective

2006 : $80,000

2007 : $60,000

2008 : $68,000

Primary RFCD 3402 APPLIED ECONOMICS

Administering Institution The University of Queensland

Project Summary

The project could provide significant benefits to Australia. Australia is a dry continent with fragile natural resources, and a

significant exporter of agricultural products. A sound knowledge of the factors that affect agricultural sustainability is crucial.

Perhaps more importantly, identifying economic, environmental, social, institutional and political factors that influence

agricultural sustainability in other countries, especially our Asian neighbours, will provide valuable information to relevant

agencies in designing strategies aimed at ensuring that these countries are stable and well fed. This is of particular

importance in the current climate, with growing influences of terrorist organisations in places where poverty exists.

DP0664045 Prof PC Almond

Approved Protestant Apocalypticism, the Book of Revelation, and History in English Thought, 1550‑1800

Project Title

2006 : $51,070

2007 : $31,070

2008 : $50,000

Primary RFCD 4402 RELIGION AND RELIGIOUS TRADITIONS

Administering Institution The University of Queensland

Project Summary

This project will make a further significant contribution to Australia's strong international reputation in Early Modern Thought.

It is crucial to Australians' understanding of our contemporary world in which Apocalyptic dualism, particularly the

demonisation of the other by both Western conservative elites and Christian and Muslim fundamentalists,is a central feature

of modern discourse. With conservative religious movements which treat the Bible literally significantly on the increase in

Australia, it is crucial to the national interest to be aware of the socially divisive elements in both Biblical fundamentalism and

contemporary Protestant sectarian Apocalypticism.

DP0664320 Dr AJ Bellamy; Dr PD Williams

Approved The Regionalisation of Peace Operations: Legitimacy, Effectiveness and Stable Peace

Project Title

2006 : $90,000

2007 : $45,000

2008 : $60,000

Primary RFCD 3601 POLITICAL SCIENCE

Administering Institution The University of Queensland

Project Summary

Through its deployments in East Timor, the Solomon Islands, PNG and elsewhere, Australia has led the world in thinking

about innovative ways of conducting peace operations. It is well‑understood that peace operations in failed states can help to

prevent terrorism by removing the conditions in which they prosper. To date, however, there has been no rigorous

conceptually informed historical and contemporary research on precisely which types of actors are most effective. This

project will add significantly to global understandings of peace operations and make an important contribution to Australian

policy decisions about how best to maximise effectiveness.

DP0666891 Miss SM Bengtson Nash; Prof MR Moore; Prof Dr W Vetter; Prof MA Lang; Dr S Kawaguchi

Approved Assessment of the Risks Posed to an Antarctic Keystone Species, Antarctic krill (Euphausia

Project Title superba), Through Exposure to Persistent Organic Pollutants

2006 : $240,000

2007 : $180,000

2008 : $180,000

Primary RFCD 3008 ENVIRONMENTAL SCIENCES

APD Miss SM Bengtson Nash

Administering Institution The University of Queensland

Project Summary

POPs are subject to a global treaty seeking to reduce and eventually eliminate these chemicals from the environment.

Inhibiting the development of effective intervention strategies is a lack of knowledge regarding biological dose‑response and

cause‑effect relationships. The proposed study will develop multiple endpoint assays to investigate these species‑specific

relationships and undertake a multidisciplinary risk assessment of increasing POP levels to E. superba. The research will

fulfil national treaty requirements and represents an excellent opportunity to advance the field of polar and marine POP

ecotoxicology. Outcomes will be critical for the sustainable management of a commercial resource and a pressured keystone

species.

DP0666369 Dr AI Bishop

Approved Development of a neutral helium beam microscope

Project Title

2006 : $165,000

2007 : $80,000

2008 : $80,000

Primary RFCD 2403 ATOMIC AND MOLECULAR PHYSICS; NUCLEAR AND PARTICLE PHYSICS; PLASMA

PHYSICS

APD Dr AI Bishop

Administering Institution The University of Queensland

Project Summary

This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing

nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the

emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field.

The project will develop a prototype instrument which is aimed at becoming a commercially viable product ‑ the neutral

helium beam microscope. The possibilities of using the microscope system as a nanofabrication device would also give

researchers in Australia the ability to fabricate structures that could not be manufactured anywhere else in the world.

DP0663485 Prof RJ Capon; Dr R Lewis; Dr MD Norman

Approved Novel Sodium Ion Channel Modulators From Australian Cephalopods.

Project Title

2006 : $110,000

2007 : $90,000

2008 : $90,000

Primary RFCD 2503 ORGANIC CHEMISTRY

Administering Institution The University of Queensland

Project Summary

Many Australian cephalopods (octopuses, squids, cuttlefishes and nautiluses) use potent toxins to rapidly paralyse diverse

prey and defend against predators. These toxins act by the efficient blocking of ion channels critical to the transmission of

nerve impulses. Knowledge of these toxins can lead to safer and better drugs for the relief of chronic pain.

DP0665821 Prof RG Carson; Asst Prof AG Cresswell

Approved An inverse control approach to resolving the neural basis of spatial and muscular dependencies in

Project Title coordinated multi‑limb movements

2006 : $70,000

2007 : $65,000

2008 : $70,000

Primary RFCD 3801 PSYCHOLOGY

Administering Institution The University of Queensland

Project Summary

Each year 48,000 Australians suffer from stroke with many survivors left with problems that limit limb function. With reduced

duration of hospital care, the opportunities for retraining in the period immediate following stroke are rapidly diminishing.

Effective and efficient strategies of rehabilitation that will maximise the level of recovery following stroke will result in benefits

expressed in terms of enhanced quality of life and functional life‑span, as well as significantly reduced costs of health care. In

understanding the fundamental principles underlying the stability and adaptability of movement coordination, this research is

likely to make a significant contribution to the design of programs for movement rehabilitation.

DP0663144 Dr KL Cheney

Approved The function and maintenance of aggressive mimics: the cleaner fish ‑ fangblenny system

Project Title

2006 : $140,000

2007 : $118,000

2008 : $118,000

Primary RFCD 2707 ECOLOGY AND EVOLUTION

APD Dr KL Cheney

Administering Institution The University of Queensland

Project Summary

Mimicry is an important biological phenomenon, which is studied extensively by scientists. However, only 5% of papers that

were published on mimicry systems in the last five years were from Australian institutes, yet mimicry is ubiquitous in

Australia. Therefore, this study will enhance the recognition of Australian research on the international stage in mimicry

studies, animal communication systems and behavioural ecology. This work will aid communication of biology to the general

public, as mimicry is a celebrated example of Darwinian adaptation and stories about coral reefs are interesting and intuitive.

This study will also provide empirical data to support theoretical development of mimicry theory.

DP0664869 Dr SF Chenoweth

Approved A Genomic Dissection of Natural Adaptation in Mate Recognition

Project Title

2006 : $180,000

2007 : $125,000

2008 : $125,000

2009 : $125,000

2010 : $125,000

Primary RFCD 2702 GENETICS

ARF Dr SF Chenoweth

Administering Institution The University of Queensland

Project Summary

Adaptation is a fundamental area of evolutionary biology but we know surprisingly little about its underlying genetic basis. As

a process, adaptation poses several challenges for Australian society including bacterial evolution of resistance to antibiotics,

HIV resistance to antiviral medications and the evolution of pesticide resistance in agricultural pests. This study will use a

model system and genomic tools to test theoretical models of the genetic basis of adaptation. This integrative approach will

enhance Australia's research profile in genomics and evolutionary biology. The project will provide emerging scientists with

skills in areas including genomics, molecular biology, evolutionary biology and agricultural genetics.

DP0664092 Dr BM Collins

Approved The molecular mechanism of retromer and sorting nexin function in endosomal membrane

Project Title trafficking

2006 : $71,000

2007 : $71,000

2008 : $71,000

Primary RFCD 2701 BIOCHEMISTRY AND CELL BIOLOGY

Administering Institution The University of Queensland

Project Summary

The proposed research represents breakthrough science that will lead to a fundamental understanding at the molecular level

of the structure and assembly of the retromer complex and how it regulates sorting of receptors in the endosomal system. It

will provide excellent research training for top graduate students and post‑doctoral scientists in multidisciplinary methods that

constitute state‑of the‑art structural and molecular cell biology research. By addressing an area of great interest

internationally the project will have the capacity to increase Australia's knowledge base and strengthen it's reputation for

research excellence.

DP0666020 Prof M Colyvan; Dr DG Hyde

Approved A Paraconsistent Approach to Vagueness

Project Title

2006 : $77,801

2007 : $80,446

2008 : $75,641

Primary RFCD 4401 PHILOSOPHY

Administering Institution The University of Queensland

Project Summary

This project will utilise logical techniques that have been developed largely by Australian logicians. This techniques will be

brought to bear on the problem of vagueness, one of the most important problems in the philosophy of logic. The project will

thus greatly enhance Australia's already strong international reputation in logic and philosophical logic.

DP0662820 Dr HM Creese

Approved Sketches of Bali in 1830: The unpublished letters and papers of Pierre Dubois, Dutch agent at Kuta,

Project Title 1828‑1831

2006 : $60,000

2007 : $25,000

2008 : $41,000

Primary RFCD 4301 HISTORICAL STUDIES

Administering Institution The University of Queensland

Project Summary

The primary benefit of this work is its scholarly contribution to knowledge of Indonesian history in the nineteenth century.

Perceptions of Bali forged in the colonial period provide the foundation on which contemporary ideas of identity are

constructed. These images, notably those pertaining to Bali's Hindu religion and unique culture, remain important to

contemporary Indonesian regional identities. They also point to some of the complex interconnections across Western and

Indonesian cultures. As Australia‑Indonesia relationships enter a more optimistic phase, this historical research thus has the

potential to broaden our understandings of cultural differences to enhance Australia's capacity to interpret regional issues.

DP0664103 A/Prof FB D'Agostino

Approved Using empirical materials to inform normative thinking about the organization of groups for the

Project Title production of knowledge

2006 : $48,776

2007 : $20,000

2008 : $48,776

Primary RFCD 4401 PHILOSOPHY

Administering Institution The University of Queensland

Project Summary

It is increasingly apparent that knowledge is produced by organized groups‑e.g. research or management teams. The idea of

heroic individual creators is still presented in popular media, but has little credence in hard‑headed organizational contexts,

where, e.g., Wenger's idea of the community of practice plays an important role in steering policy and institutional

development. Finding out how we can organize collectives so that they can function WELL as producers of knowledge is the

aim of this project in social epistemology. Its success will contribute directly to theoretical discourse about innovation in

organizations and promises to contribute indirectly to the improvement of the institutional bases of our cultural and economic

capital.

DP0662882 A/Prof RG Duggleby; Prof Z Li

Approved Development of new herbicides targeting enzymes involved in the biosynthesis of branched‑chain

Project Title amino acids

2006 : $94,000

2007 : $89,000

2008 : $89,000

Primary RFCD 2701 BIOCHEMISTRY AND CELL BIOLOGY

Administering Institution The University of Queensland

Project Summary

Modern agriculture is heavily reliant on the use of herbicides. An inevitable consequence of herbicide usage is that resistant

weeds will develop. Therefore, there is a continuing need to develop new herbicides to kill these resistant species. Herbicides

interact with vulnerable molecular targets in plants, such as photosynthesis or the biosynthesis of certain amino acids. This

project will attempt to develop new herbicides that act upon two molecular targets that are not exploited by herbicides that are

used currently. We will design, synthesize and test a variety of new compounds as potential environmentally‑benign

herbicides.

DP0662927 Prof RE Elson

Approved The origins and trajectory of secularism in modern Indonesian politics

Project Title

2006 : $47,000

2007 : $44,000

2008 : $36,000

Primary RFCD 4301 HISTORICAL STUDIES

Administering Institution The University of Queensland

Project Summary

This reseach will provide both historical perspective and contemporary analysis of the vexed problem of secularism in

Indonesian politics. It will provide a more nuanced understanding of the complexities of the secularist bent in Indonesian

political history and thinking, and will assist commentators, scholars and policy makers better to appreciate Indonesia's

continuing struggle to create, construct and maintain a secularist polity.

DP0664486 Dr DS Ferber

Approved Medicine and Culture: Bioethics in Historical Perspective, 1850 to the present

Project Title

2006 : $62,000

2007 : $20,000

Primary RFCD 4301 HISTORICAL STUDIES

Administering Institution The University of Queensland

Project Summary

Australia has long been looked to as an example for legislative and community responses to new medical technologies and

as a leader in debates about medical ethics. The project will contribute to the international profile of Australia as a leader in

health policy issues, as well as sustaining a focus on informed community debate.

DP0663718 Dr Z Ficek

Approved Entanglement Processing in N‑Atom Systems

Project Title

2006 : $74,000

2007 : $74,000

2008 : $74,000

Primary RFCD 2404 OPTICAL PHYSICS

Administering Institution The University of Queensland

Project Summary

An essential part of modern technological society is an understanding the scientific explanation of the world around us, and a

realization that these explanations must be critically tested in the light of technological advances. The study of multi‑atom

entanglement is closely related to questions of fundamental physics. A breakthrough in stimulating this problem could have

applications in other areas of physics and in technology, such as information processing and cryptography.

DP0666256 Prof CE Franklin

Approved The inhibition of muscle disuse atrophy in burrowing frogs

Project Title

2006 : $184,000

2007 : $165,000

2008 : $165,000

2009 : $165,000

2010 : $165,000

Primary RFCD 2706 PHYSIOLOGY

APF Prof CE Franklin

Administering Institution The University of Queensland

Project Summary

Prolonged muscle disuse, as a consequence of limb immobilisation, extended bed‑rest or space travel, can lead to

pathological changes resulting in muscle wasting. By examining a unique Australian frog that burrows underground and

remains immobile for 9‑12 months, and which shows no muscle wasting, we will significantly advance our understanding of

the physiological mechanisms that inhibit muscle atrophy.

Benefits of conducting this research will include:

‑ understanding the role of antioxidants and endogenous opioids in reducing muscle wasting

‑ training of postgraduate students

‑ stimulating collaboration between The University of Queensland and CSIRO Livestock Industries.

DP0663300 Prof PR Freebody; Dr CA Christensen; Dr NM Bahr; Dr AH Wright

Approved Disciplinarity and classroom practice: Epistemological issues in the analysis and improvement of

Project Title teaching and learning.

2006 : $94,000

2007 : $83,000

2008 : $92,000

Primary RFCD 3301 EDUCATION STUDIES

Administering Institution The University of Queensland

Project Summary

Demands on levels of content and technical knowledge are accelerating from many employment sectors in Australia and

elsewhere. In addition, there is an increasing need to apply knowledge to complex problems in innovative and flexible ways

and in authentic settings not readily simulable in traditional schooling. The proposed project addresses fundamental

questions about epistemology, curriculum, and everyday classroom practice. It offers novel and evidence‑based approaches

to the building of discipline‑based knowledge, and thus has powerful implications for the revitalising of Australian education to

meet the urgent requirements of new economic, technological, and cultural times put pressures on education.

DP0665316 Dr C Gaus; Dr R Weber; Dr B Kuch

Approved Formation, degradation and migration of a yet unidentified POP source

Project Title

2006 : $100,000

2007 : $80,000

2008 : $80,000

Primary RFCD 3008 ENVIRONMENTAL SCIENCES

Administering Institution The University of Queensland

Project Summary

Australia has recently ratified the Stockholm Convention, targeting persistent organic pollutants (POPs) for global reduction

and elimination. A significant gap exists, however, in understanding sources and pathways of POPs in Australia, and

subtropical/tropical environments. Previous research has shown an extensive POP contamination in coastal Australia, and

exposure of biota to elevated levels. The present study will evaluate the formation, degradation and migration of POPs, and

their significance to Australia's past, present and future emissions. The outcomes will allow identification of sources, their

prioritization for elimination and exposure prevention, and ultimately serve to protect the environment and human health in

Australia.

DP0665426 A/Prof IR Gentle; Prof GJ Ashwell; Dr GJ Foran

Approved Greatly improved rectification by molecular diodes

Project Title

2006 : $95,000

2007 : $88,000

2008 : $90,000

Primary RFCD 2501 PHYSICAL CHEMISTRY (INCL. STRUCTURAL)

Administering Institution The University of Queensland

Project Summary

Society has already seen dramatic benefits from microtechnology, which has made possible most of the devices that we take

for granted. The limits of miniaturisation using current technology are rapidly being reached, and the next stage is in the

realm of nanotechnology. The goal of the field known as molecular electronics is to reach the point where electronic

components are composed of single molecules or single molecular layers. In this field the smallest active component is the

molecular diode, and this project is focussed on achieving practical performance from molecular diodes, as a crucial first step

in achieving miniaturisation far beyond anything now possible.

DP0662750 Prof TJ Gonda; Dr S Ishii

Approved Function and regulation of the Schlafen gene family: novel regulators of blood cell proliferation

Project Title and function.

2006 : $88,000

2007 : $88,000

2008 : $88,000

Primary RFCD 2701 BIOCHEMISTRY AND CELL BIOLOGY

Administering Institution The University of Queensland

Project Summary

The immediate outcomes of the proposed research will be in fundamental knowledge and understanding of important cellular

and biological processes in which the Schlafen genes are involved. In particular, Schlafen genes are likely to play a role in

inflammatory responses and in blood cell growth. These process clearly have relevance to a range of major human (and

animal) diseases including infectious disease, auto‑immune disease and leukaemia, and thus a long‑term outcome may be

improved treatments for such disease.

DP0666126 Dr GJ Goodhill



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