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Title: Climatic impacts of landcover change in Australia: quantifying and modelling effects at local, regional and continental scales

Summary:

The project will quantify for the first time in Australian, the impact of land cover change on regional climate. Findings from the study will provide recommendations for future policy, planning and management of land cover change in grazing and cropping lands, with particular significance to resource sustainability and greenhouse strategies. Under supervision, a PhD candidate will evaluate the impact on climate variables, of land cover changes at continental, regional (state) and local scales, exploring pre-European and more recent impacts. International and local linkages to modelling expertise and data base access will be leveraged to run state-of-the-art regional climate models on the DNR supercomputer.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

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2701 BIOCHEMISTRY AND CELL BIOLOGY

C00001973

Dr PV Attfield A/Prof DA Veal Dr BJ Walsh Dr R Van Rooijen

2000: $111,126.00

2001: $113,257.00

2002: $115,383.00

Administering Institution: Macquarie University

Title: Exploiting flow cytometry and proteomics to generate novel yeast strains for industrial applications

Summary:

Yeasts, which ferment sugars to produce carbon dioxide and alcohol, are used to leaven breads and to manufacture beers, wines and distilled spirits. More proficient yeasts are needed that can withstand stresses of drying and rehydration, and high osmotic pressures encountered in industrial applications. This research applies advanced technologies of flow cytometry (to analyse and isolate yeast populations and individuals), and proteomics (to study the protein complement of cells) to assist in identifying key proteins and genes involved in stress resistance of yeast strains. Based on knowledge gained, strategies will be developed and implemented to generate novel yeasts for industry.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

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C00001876

Dr PR Gooley Dr SD Scrofani Dr AD Nash

2000: $60,000.00

2001: $60,000.00

2002: $60,000.00

Administering Institution: The University of Melbourne

Title: NMR structural characterisation of vascular endothelial growth factor - B

Summary:

The VEGF family of growth factors plays a significant role in pathologicalangiogenesis and may represent a new approach to the treatment of occlusiveartery disease. This project, a collaboration between the University ofMelbourne and AMRAD, aims to determine the structure of VEGF-B, both freeand bound to its receptor, VEGF-R1 and examine the role of dynamics inreceptor binding. This information will broaden the understanding ofstructure and dynamics in receptor binding within the VEGF family. Theproject will also aid in the design of VEGF-B antagonists and explore thepotential of VEGF-B as a therapeutic.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI):

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C10027052

Dr SE Hamilton Prof J de Jersey Dr L Guddat

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: The University of Queensland

Title: Biochemical analysis of proteases from ginger with commercial potential

Summary:

The aim of the project is to characterize the biochemical properties of the protease enzymes present in ginger. The enzymes are members of the plant thiol protease family of which papain is the best characterized. Papain finds broad application in the food, cosmetic and textile industries, currently worth ~ $US 0.5 billion. The ginger proteases are currently unexploited commercially, and no comparison of their properties with papain has been undertaken. Preliminary investigations indicate that ginger proteases may offer advantages over papain in at least one application, as a meat tenderizer. This project will provide a biochemical profile of the ginger enzymes, to be used in evaluating their commercial potential.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

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C10027200

Dr PF Nixon Prof DJ Winzor Dr JA Robertson

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: The University of Queensland

Title: Milk folate binding protein: interactions affecting its function

Summary:

Milk folate binding protein (FBP) will be characterised, particularly its binding folate vitamins, its polymerization behaviour and how these characteristics interact. Folate binding will be optimised while minimising FBP polymerisation. Other milk components that stabilize FBP will be identified. This strategic research will assist research on the effect of FBP on human folate nutrition (of current value to the industry) and underpin future industrial applications of FBP in foods. Both the food industry and academia need more scientists trained in physical biochemistry of proteins; such training will be provided to the student supported by the APA(I) requested.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

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2702 GENETICS

C00002333

Dr E Pang Dr J Brouwer

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: Royal Melbourne Institute of Technology

Title: Mapping of genes controlling resistance to ascochyta blight (Mycosphaerella pinodes) in grasspea (Lathyrus sativus)

Summary:

The project will locate two genes controlling resistance to ascochyta blight (M. pinodes) in grasspea (L. sativus). Ascochyta blight is the most serious disease of field pea (P. sativum)in Australia and worldwide. Presently there is no effective source of resistance to this disease within the Australian field pea breeding program, of which the Victorian Institute for Dryland Agriculture (VIDA)is a key participant. The proposed project will characterise, locate, and produce molecular tags (markers) to two previously identified genes in a related species, grasspea. Molecular markers to these resistance genes may be used in subsequent studies to aid in cloning these genes for incorporation into field pea.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C00002115

Dr R Peakall Mr SR Gilmore Dr J Robertson

2000: $50,000.00

2001: $50,000.00

2002: $50,000.00

Administering Institution: The Australian National University

Title: Development and application of powerful new DNA tools for investigative forensics and agricultural utilisation in Cannabis sativa

Summary:

This project will develop and use new DNA profiling methods (STRs) in Cannabis sativa that can withstand forensic and legal scrutiny for: (1) discriminating among low-and high-drug varieties, and (2) for identifying the origin of seized drugs. This will provide a powerful new investigative tool for intelligence analysis of organised and commercially motivated criminal activity. These methods will also aid the expanded licensing of low-drug cannabis by: (1) assisting in the identification of agricultural varieties for Plant Breeders Rights registration, and (2) providing tools for monitoring seed stock purity, marker assisted plant breeding and genetic mapping.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI):

******

C00001952

Dr P Batterham Prof JA McKenzie

2000: $85,000.00

2001: $90,000.00

2002: $90,000.00

Administering Institution: The University of Melbourne

Title: Molecular targets of insecticides and mechanisms of resistance

Summary:

The development of chemicals designed to control insect pests is extremely time consuming and expensive. When pests become resistant to an insecticide, new chemicals need to be discovered adding to the costs. This project will use a model insect, the vinegar fly Drosophila melanogaster, to investigate the molecular basis of resistance. In collaboration with scientists at Novaris Animal Health Australasia P/L we will use this knowledge to curb resistance in pest species and to design a new generation of more effective insecticides. Protocols being trialed in this project may ultimately be adopted globally by the chemical industry.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI):

******

C00002506

Prof BP Kinghorn Dr GP Davis Dr DJ Hetzel

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: The University of New England

Title: Strategies to minimise DNA testing costs for research and development programs involving pedigreed populations.

Summary:

There has been a dramatic increase in genotyping of pedigreed populations for known genes and genetic markers. However, costs are too high for many potential applications. This project aims to develop strategies based on complex segregation analysis to considerably reduce the number of DNA tests that need to be carried out for a given utility of information. A theory paper has been published in Genetics, and a simple example application is in press. This project will extend these methods to optimise them for prevailing genotyping tasks, and give a basis for practical application in industry.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C00002179

Dr WB Sherwin Mr K Morris Mr PB Copley Dr RA Rissman Dr TP Fletcher Prof RV Baudinette

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: The University of New South Wales

Title: Validating Genetic Management of Stick-Nest Rats

Summary:

As more and more species face extinction through human-induced causes, conservation programs are using captive management to provide stock for reintroduction into restored habitat. We will conduct a rarely-performed check of the concepts and methods underpinning genetic management of such programs, focusing on captive breeding and reintroduction of the natianally threatened stick-nest rat. The opportunity to carry out this study relies on the foresight of the industry partners, who stored small tissue samples throughout the program, and still maintain the captive colony, allowing us to examine genetic changes and their effect on development, survival and reproduction.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C00002319

Dr AN Wilton Dr F Lingaas

2000: $31,080.00

2001: $31,080.00

2002: $31,080.00

Administering Institution: The University of New South Wales

Title: Disease gene identification border collie dogs

Summary:

Aim is to identify disease genes that cause common disorders in border collies. Collie eye anomaly (CEA) is a common congenital defect that can result in blindness. Ceroid lipfuscinosis (CL) is a nerve degenerative disease with onset about 18 months. Both diseases are a problem for pedigree border collie breeders but the late age of onset of CL means that a number people are affected by the loss. Identification of the disease genes will lead to DNA test for carriers of the disease genes. Selective breeding will then allow elimination of these disorders from the breed.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C10010010

Prof RL Raison Dr BA Baldo Dr GR Donovan

2000: $60,908.00

2001: $62,066.00

2002:

Administering Institution: University of Technology, Sydney

Title: A genetically engineered immunotoxin incorporating a cytolytic peptide from ant venom

Summary:

A targeted cytotoxic agent (immunotoxin) using a cytolytic peptide (pilosulin) from ant venom will be developed. In previous studies we produced a unique, recombinant immunotoxin incorporating the bee venom toxin, melittin. While this immunotoxin yielded promising results, there is a clear need to improve the design in order to increase the specific activity to a level where it may be used as a therapeutic agent. As pilosulin is intrinsically more toxic than melittin and has patent protection, we propose that a pilosulin-based immunotoxin will result in a more effective, and commercially viable, reagent for the treatment of selected cancers.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C00001913

Prof RJ Whelan A/Prof DJ Ayre Dr P England

2000: $42,160.00

2001: $42,160.00

2002: $42,160.00

Administering Institution: University of Wollongong

Title: Ecology of fire-sensitive Persoonia species: threatened species recovery and management

Summary:

Many threatened plant species may face similar threats and share characteristics such as life history and response to disturbances (e.g. fire and population fragmentation). A multi-species approach to species recovery would be efficient and effective, but has rarely been attempted. These two projects will compare the demography (fire responses, reproductive success, seed dispersal and seed predation) and population genetics (mating systems, gene flow, selection) of a set of rare and threatened Persoonia species with co-occurring common species. Results will be directly applicable to recovery planning by predicting site persistence of the threatened species and assessing management options.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 2

******

C00002460

Dr S Baindur-Hudson Dr R VanOorschot

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: Victoria University of Technology

Title: Use of Polymorphisms in Genes to Predict Physical Characteristics of Individuals from DNA Samples

Summary:

Currently used forensic tests can compare DNA profiles from samples left at the scene of a crime with those derived from identified suspects. However, many crimes involve unknown or unsighted suspects. The currently used genetic markers do not provide information regarding distinguishable physical features of individuals, rather they use non-coding short tandem repeat (STR) regions. This project aims to investigate the use of genetic polymorphisms in coding regions to predict the physical characteristics of an unknown suspect such as eye colour, attached/unattached earlobes, left/right-handedness, hair colour, etc. The resulting information would be linked with the International Human Genome Project and be of direct benefit to forensic crime analysis.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

2703 MICROBIOLOGY

C00002207

A/Prof B Dell Dr N Malajczuk

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: Murdoch University

Title: Effect of host institution on development of the black truffle in Western Australia

Summary:

The farming of the Black Truffle in Australia is at an early stage but the industry has the potential to contribute to Australia's export of fine foods. The project will investigate how managing the fertilzer regime to the host hazel tree can enhance carbohydrate flow to the roots thus encouraging the development of the truffle fungus in the soil root system. Soil fertility is one of the major management tools available to the industry and this project will result in recommendations for the industry which are based on science.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C00002098

A/Prof MA Deighton Prof P Coloe

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: Royal Melbourne Institute of Technology

Title: Identification of bovine streptococci on the basis of polymorphisms in Heat Shock protein 60 (HSP60) gene sequences

Summary:

Mastitis costs the Australian dairy industry approximately $120 million annually. Bovine streptococci are the second most important bovine pathogens, contributing significantly to high somatic cell counts in milk (poor quality milk). Current methods for the identification of bovine streptococci are inaccurate and slow (at least 48 hours). The aim of this project is to develop a multiplex PCR assay that would provide a rapid a specific identification of bovine streptococci. This would allow appropriate corrective action to be taken, e.g. early treatment of infected animals to prevent cow to cow transmission or removal of an environmental source of infection.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C00002139

A/Prof NJ Ashbolt Dr JE Ongerth Dr P Nadebaum Dr PF Teunis

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: The University of New South Wales

Title: Dispersion, transport nad persistence of viable Cryptosporidium oocysts in catchment soils and raw water reservoirs.

Summary:

Most risks from microbial pathogens in drinking waters are considered to be associated with events, with high numbers in catchment waters and treatment failure being the most important. Treatment in many Australian drinking water systems, however, is simply by reservoir storage and chlorination. Hence, for the chlorine resistant pathogen, Cryptosporidium, this project aims at assessing the fate of their oocysts in catchment animals' faecal deposits and sewage, their dispersion when washed into rivers, and their sedimentation (free or associated with particulates) and "viability" during containment in raw water reservoirs. A major outcome will include model parameters that integrate with the industry members microbial risk assessment of whole water systems.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C10027202

Dr ML Smythe Prof MJ Waters

2000: $110,000.00

2001: $115,000.00

2002: $115,000.00

Administering Institution: The University of Queensland

Title: The development of small molecule growth hormone agonists

Summary:

This project describes a collaboration between The University of Queensland and Novo Nordisk for the rational design of small molecule agonists of human growth hormone. Novo Nordisk is one of the largest producers of recombinant Growth Hormone for use in the clinic. This project addresses a significant problem in the pharmaceutical industry: how to discover small molecule agonists of large macromolecular cytokines or growth factors that function by receptor oligomerisation. This project develops and explores the combination of structure based de novo design, combinatorial chemistry and high throughput screening to achieve these objectives. The outcomes of this project will ideally be a small molecule Growth Hormone agonist that will have the potential to treat many Growth Hormone disorders, and a better understanding of what is required for the development of small molecule agonists of cytokines. In addition, the close links between Australian research and international companies and the strengthening of an intellectual property base will contribute to further development of an Australian based pharmaceutical R&D industry.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI):

******

2704 BOTANY

C00002253

Prof AR Hardham Dr JS Marshall

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: The Australian National University

Title: Identification and characterisation of Phytophthora sporulation genes: targets for the development of novel control strategies

Summary:

The aim of this project is to identify and characterise Phytophthora genes which function in the production of infective spores. Species of Phytophthora cause widespread, destructive diseases in many important agricultural crops and forest plants. Currently control methods are limited, and new and sustainable methods of control are urgently needed. Phytophthora genes that are specifically required for sporulation are targets for the development of novel methods of controlling Phytophthora diseases. Once identified, the activity of these targeted proteins could be inhibited either by chemical fungicides or by the products of transgenes introduced into crop plants.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C00002522

Dr JW Randles Dr RC Magarey Dr GR Smith

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: The University of Adelaide

Title: Determining the causal agent of chlorotic streak disease of sugarcane.

Summary:

The sugar industry earns $2 billion annually for the Australian economy and sugar is the second largest agricultural export commodity. Chlorotic streak is a biotic disease widespread in Australia, causing significant yield losses in 50,000 ha annually. It has been recognised since 1929. The causal agent is unknown, but evidence suggests that the disease has a virus etiology. Molecular techniques will be used to identify the causal agent and develop assays for providing pathogen tested plants for new crops and for improving management practices to control the disease.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C00002632

A/Prof JW Patrick Dr DW McCurdy

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: The University of Newcastle

Title: Genetic engineering of enhanced sweetness and flavour in tomato fruit

Summary:

This project addresses a major international agronomic imperative to enhance flavour of tomato fruit by increasing sugar levels. Our studies demonstrate that sugar transporters, located in fruit storage cells, regulate sugar accumulation, and we have cloned their encoding genes. Thus, all the elements are available to undertake an innovative molecular genetics approach to increase fruit sugar levels. Collaboration with Yates Vegetable Seeds Pty. Ltd. provides access to transformation technologies and ultimately breeding programs for commercialization of successful outcomes. The proposed research offers an exciting PhD project in an area of contemporary plant science and technology that has potential to contribute improvements in crop productivity that will be of international significance.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C00002478

A/Prof K Sivasithamparam A/Prof J Kuo Dr K Dixon

2000: $57,000.00

2001: $57,000.00

2002: $57,000.00

Administering Institution: The University of Western Australia

Title: The role of mycorrhizal interactions in the urban ecology, management and restoration of terrestrial orchids

Summary:

A diverse terrestrial orchid flora occurs in southwestern Australia. Orchid populations are often the first herbaceous elements to vanish following urbanisation, and therefore their persistence can be used to define the fitness and integrity of urban ecosystems. Becuase terrestrial orchids require an endophytic fungal partner for germination, growth and development, this projects aims to identify factors which affect the distribution and persistence of the endophyte in the soil, and in turn, the survival of the plant. A key outcome will be the ability to restore self-perpetuating orchid populations into rehabilitated urban bushland and use orchids as bio-indicators of bushland conditions.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI):

******

C00001999

A/Prof JP Conroy Dr KD Montagu A/Prof V Sarafis Dr RL Dickson Ms S Ash

2000: $60,000.00

2001: $60,000.00

2002: $60,000.00

Administering Institution: University of Western Sydney

Title: Developmental processes controlling wood density under different environments

Summary:

Denser wood stores more carbon, is stronger when used for construction and makes higher quality paper - this translates into greater economic benefits for plantation and farm forestry. But what are the individual environmental factors which influence wood density of Australia's pines and eucalypts? These questions will be addressed by using innovative techniques to investigate effects of temperature, atmospheric CO2, and water and nutrient supplies on wood development. Emphasis on developmental processes will illuminate how trees adapt to the environment and will provide valuable information for forest management and for genetic modification of trees to suit particular environments.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI):

******

2705 ZOOLOGY

C00002572

Dr B Knott

2000: $21,080.00

2001: $21,080.00

2002: $21,080.00

Administering Institution: The University of Western Australia

Title: Reproduction biology and culture of sea cucumber (Echinodermata: Holothuroidea) in Northern Australia

Summary:

The aim is to acquire knowledge of sea cucumber reproductive biology from which a new mariculture industry in Northern Australia can be established. The industry will reduce significantly the pressures on the wild capture industry and will provide economic benefits to Australian indigenous and non-indigenous populations. The biological information gained from the study will provide the frame work for commercialistion of a sea cucumber mariculture industry.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

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2706 PHYSIOLOGY

C00001980

Prof DW Cooper Mr S Smith-White Dr TE Trigg Dr TP Fletcher Mr DH Lunney A/Prof JM Joss Mr JI Minor

2000: $50,000.00

2001: $45,000.00

2002:

Administering Institution: Macquarie University

Title: Contraception for population management of koalas, kangaroos and deer

Summary:

Fertility control is the only socially and politically acceptable method of regulating wildlife populations in many instances. An effective long acting contraceptive for companion animals is being developed by an Australian company, Peptech Animal Health Pty Ltd. This project will investigate the effectiveness of this agent (Deslorelin) on koalas, kangaroos and deer. The outcome is expected to be a more humane method of population management and an increase in the range of species for which Peptech can market Deslorelin.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):

Number of Australian Postgraduate Award(s) Industry places (APAI): 1

******

C00002422

Dr JK O'Brien Dr G Evans Dr JR Giles Dr WM Maxwell

2000: $57,000.00

2001: $57,000.00

2002: $59,000.00

Administering Institution: The University of Sydney

Title: Development of sperm sexing and assisted reproductive technology for the production of pre-sexed offspring in the gorilla and chimpanzee

Summary:

Male gorillas are expelled from their family groups at sexual maturity, necessitating expensive and unethical individual housing in zoos. The production of pre-sexed farm animals has recently been demonstrated using sperm sorting techniques and artificial insemination. This technology will be developed for the gorilla and chimpanzee, and novel methods for storage and in vitro manipulation of sorted sperm will be designed. This research will benefit captive breeding programs through structuring the sex ratio of groups to resemble those in the wild. Selectively producing females of these and other endangered species will more quickly propagate dwindling populations.

Number of Australian Postdoctoral Fellowship Award(s) Industry (APDI):1

Number of Australian Postgraduate Award(s) Industry places (APAI):

******

2707 ECOLOGY AND EVOLUTION



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